D’Amore is currently Director of the Howe Laboratoy at Mass. Eye and Ear, as well as the Director of Research, Senior Scientist and the Ankeny Scholar of Retinal Molecular Biology at Schepens. Her research focuses on understanding the mechanism of vascular growth and development. She is particularly interested in the role of polypeptide growth factors such as VEGF and TGF-ß and in investigating the contribution of cell-cell interactions in the cells of the vasculature. She has over 211 publications to her credit, some of which have appeared in journals such as Nature Medicine, Journal of Clinical Investigation, Development, and Journal of Cell Biology.